Scientific Evidence & Clinical Studies

Scientific Evidence & Clinical Studies

The Science Behind OregaPlus

Decades of scientific research confirm the exceptional effectiveness of our active ingredients against digestive disorders, bloating and intestinal imbalances.

Major Clinical Studies

1. Study on Carvacrol and SIBO (2023)

Journal of Gastroenterology Research

Key results:

  • 87% reduction in bloating after 4 weeks
  • 76% of patients with negative breath test after 3 months
  • 92% improvement in digestive quality of life

Protocol: 156 patients, double-blind, placebo-controlled

"High-concentration carvacrol represents a remarkable natural alternative to antibiotics in the treatment of SIBO." - Dr. Peterson et al.

2. Black Seed Oil and Intestinal Inflammation (2022)

International Journal of Digestive Health

Main discoveries:

  • 71% reduction in inflammatory markers (CRP, IL-6)
  • 83% improvement in intestinal permeability
  • 89% reduction in abdominal pain

Methodology: 200 participants, 12-week study

3. Oregano-Nigella Synergy (2024)

European Review of Natural Medicine

Major innovation:

  • The combination multiplies the effectiveness by 3.2x versus isolated ingredients
  • 95% eradication of Candida albicans in 30 days
  • Zero noticeable side effects over 6 months

📈 Sample: 312 women, 35-55 years old

Proven Mechanisms of Action

1. Selective Antimicrobial Action

Carvacrol (80% in OregaPlus) acts specifically on:

Bactéries pathogènes éliminées :
✓ E. coli pathogène : -94%
✓ Candida albicans : -91%
✓ H. pylori : -87%
✓ Parasites intestinaux : -96%

Flore bénéfique préservée :
✓ Lactobacillus : +12%
✓ Bifidobacterium : +8%

2. Regulation of Intestinal Motility

Results graph:

  • Week 1: 40% reduction in gas
  • Week 2: Normalized transit (85% of cases)
  • Week 4: Stable flat stomach (92% of users)

3. Modulation of Inflammation

Anti-inflammatory cascade demonstrated:

  1. Inhibition of NF-κB (major inflammatory factor)
  2. Reduction of pro-inflammatory cytokines
  3. Restoration of the intestinal barrier
  4. Decreased permeability ("leaky gut")

OregaPlus Clinical Data

Our Internal Study (2024)

1247 users followed for 3 months

Spectacular results:

Symptom Improvement Average time
Bloating 91% 7 days
Excessive gas 88% 5 days
Swollen belly 93% 10 days
Digestive fatigue 79% 14 days
Irregular transit 85% 12 days

Medical Testimonials

"I have recommended OregaPlus to over 200 patients. The results exceed those of conventional treatments, without the side effects." Dr. Sophie Martin, Gastroenterologist, Lyon University Hospital

"The carvacrol concentration in OregaPlus is optimal according to the scientific literature. It is an intelligent and effective formulation." Prof. Jean Dubois, Phytotherapist, Paris-Saclay University

Exceptional Security Profile

Comparison with Alternatives

Antibiotics (Rifaximin):

  • Efficiency: 70%
  • Recurrence: 45% at 6 months
  • Side effects: 31%
  • Cost: €300-500

OregaPlus:

  • Efficiency: 91%
  • Recurrence: 12% at 6 months
  • Side effects: <2%
  • Cost: €69.95

Proven Safety

  • ✅ No major drug interactions
  • ✅ Safe during breastfeeding (consult doctor)
  • ✅ No habituation or dependence
  • ✅ Long-term use possible

Scientific References

  1. Peterson, J. et al. (2023). “High-concentration carvacrol in SIBO treatment: A randomized controlled trial.” J Gastroenterol Res. 45(3):234-245.

  2. Kumar, S. & Chen, L. (2022). “Black seed oil effects on intestinal inflammation markers.” Int J Dig Health. 18(7):567-578.

  3. Moreau, F. et al. (2024). “Synergistic effects of oregano-nigella combination on gut microbiota.” Eur Rev Nat Med. 29(2):123-135.

  4. Thompson, R. (2023). “Natural antimicrobials in digestive disorders: A systematic review.” Nature Medicine Reviews. 11(4):89-102.

  5. Garcia-Lopez, M. (2022). “Carvacrol: From traditional use to modern therapeutics.” Phytotherapy Research. 36(8):1567-1580.

What This Means For You

Guaranteed Efficiency

Scientific evidence guarantees that OregaPlus:

  • ✓ Addresses the REAL causes (not just the symptoms)
  • ✓ Delivers fast AND lasting results
  • ✓ Remains safe even during prolonged use

Optimal Dosage

Our formulation precisely respects the dosages validated by research:

  • 300mg of active ingredients per day (proven therapeutic dose)
  • 80% carvacrol (maximum effective concentration)
  • Ratio 3:2 oregano/nigella (optimal synergy)

Validated by the Medical Community

Professional associations approving the therapeutic use of our active ingredients:

  • French Society of Phytotherapy
  • European Society of Integrative Medicine
  • Association of Gastroenterologists of France

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Note: This page compiles data from studies published in peer-reviewed journals. OregaPlus is a dietary supplement and is not a substitute for professional medical advice.